Aging & Cognition
Klotho shows strong anti–aging benefits and also improves cognition.
Source: Kuro-O et al., Nature, 1997. Kuroso et al., Science, 2005.
The anti-aging benefits were originally discovered in Klotho genetic variants in mice and humans. The benefits have also been confirmed via Klotho injections in animals.
Klotho genetic overexpression in mice produced +30% longer life. Klotho genetic deficiency was shown to shorten life by 80%.
IMPROVED COGNITION AFTER KLOTHO INJECTION
A single injection of Klotho in mice resulted in statistically significant improvement in spatial and working memory 2 days later.
Source: Leon et al., Cell Reports, 2017.
Variation in the Klotho gene is associated with bigger brain volume and better function in human studies. In 2 cohorts of seniors, Klotho was a significant predictor of improved executive function.
Source: Yokoyama et al., Annals of Clinical and Translational Neurology, 2015.