ADVANTAGES OF KLOTHO PROTEIN

Aging/Cognition

Klotho shows strong anti–aging benefits and also improves cognition. This was originally discovered in Klotho genetic variants both in mice and humans. The benefits have now also been confirmed via Klotho injections in animals.

aging-cognition

Source: Kuro-O et al., Nature, 1997. Kuroso et al., Science, 2005.

+30% LONGER LIFE

Klotho genetic overexpression in mice produced +30% longer life. Klotho genetic deficiency was shown to shorten life by 80%.

IMPROVED COGNITION AFTER KLOTHO INJECTION

A single injection of Klotho in mice resulted in statistically significant improvement in spatial and working memory 2 days later.

Source: Leon et al., Cell Reports, 2017.

BIGGER BRAIN BETTER FUNCTION

Variation in the Klotho gene is associated with bigger brain volume and better function in human studies. In 2 cohorts of seniors, Klotho was a significant predictor of improved executive function.

brain volume
executive function

Source: Yokoyama et al., Annals of Clinical and Translational Neurology, 2015.

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