Aging & Cognition

Klotho shows strong anti–aging benefits and also improves cognition. 

Source: Kuro-O et al., Nature, 1997. Kuroso et al., Science, 2005.

The anti-aging benefits were originally discovered in Klotho genetic variants in mice and humans. The benefits have also been confirmed via Klotho injections in animals.

Klotho genetic overexpression in mice produced +30% longer life. Klotho genetic deficiency was shown to shorten life by 80%.

IMPROVED COGNITION AFTER KLOTHO INJECTION

A single injection of Klotho in mice resulted in statistically significant improvement in spatial and working memory 2 days later.

Source: Leon et al., Cell Reports, 2017.

BIGGER BRAIN

BETTER FUNCTION

Variation in the Klotho gene is associated with bigger brain volume and better function in human studies. In 2 cohorts of seniors, Klotho was a significant predictor of improved executive function.

Source: Yokoyama et al., Annals of Clinical and Translational Neurology, 2015.