ADVANTAGES OF KLOTHO PROTEIN

Cancer

Klotho shows great promise in the treatment of many types of cancer in animal studies. Klotho suppresses tumor growth, inhibits metastases, reduces resistance to chemo-therapy drugs and improves survival.  Cancer is the leading cause of death in the US and new cancer cases are expected to grow 70% over the next 20 years. Most cancers are not curable.

tumor size

Source: Ligumsky et al., Molecular Cancer Research, 2015.

SUPPRESSES BREAST CANCER GROWTH

In animals, repeated injection of Klotho significantly slowed all measures of breast cancer growth: tumor size, weight and visual appearance. Importantly, Klotho was well tolerated.

IMPROVED SURVIVAL

Klotho injections significantly improved survival in animals transplanted with cancer cells.

cancer survival

Source: Doi et al., Journal of Biological Chemistry, 2011.

metastases

Source: Doi et al., Journal of Biological Chemistry, 2011.

REDUCED METASTASES

Klotho injections significantly reduced the mean number of metastatic cancer lesions from 3 to 1 in animals that were transplanted with cancer cells.

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